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KMID : 0353320020260010109
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Oral Biology Research
2002 Volume.26 No. 1 p.109 ~ p.118
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The effect of dietary consistency on morphological changes in the mouse condyle and alveolar bone.
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Abstract
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The development and proliferation of the mandibular condyle can be altered by changes in the biomechanical environment of the temporomandibular joint. The condyle is loaded by forces applied to the teeth during mastication or biting. A reduction of functional forces delivered to the mandibular bone and joint can be achieved by providing foodstuffs that can be ingested with little or no mastication. The purpose of this study was to observe the histological changes of the effect of altered mechanical forces using diet manipulation on mouse mandibular condyle and alveolar bone.
ICR mice were provisioned with either a soft, mush diet (soft-diet group) or hard rat pellets (hard-diet group) beginning at weaning for the alteration of functional force and subsequently sacrificed at 89 days of age. By putting mice into dietary consistency of either hard diet or soft diet birth, the incisor was trimmed and made the mandibular condyle into functional or functional lowered states. incisors of mice in soft diet group were trimmed twice a week to reduce occlusal forces.
After killing the animals, mandibular bone including condyle were colleted, and demineralized with 10% EDTA, and embedded in paraffin. For the histological observation, section of mandibule were also inspected.
The results were as follows :
1. Histologic section showed that mouse fed a soft die are histologically characterized by a significantly thinner condylar cartilage and a reduction in trabecular bone density deep to the cartilage.
2. A soft-diet seems to enable a longer period of endochondral ossification in the mandibular condyle.
3. There was associated reduction in alveolar bone mass and bone remodeling. Sections showed that osteoblastic activity along the bone trabeculae and active bone remodeling were significantly lower in soft-diet than in hard-diet animals.
It is proposed that altered mechanical force by diet manipulation resulted in slowed growth in the condylar catilage and regional decrease in osteoblast function of alveolar bone.
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